Col1a1-(TRE3G-dCas9-VPR-eGFP-pA)

Description

These mice harbor a TRE3G-dCas9-VPR(VP64-p65-Rta)-eGFP-pA tetracycline-controlled transcriptional activation cassette in mouse Col1a1 loci by CRISPR/Cas mediated homologous recombination. This strain can be used in CRISPR mediated target gene transcriptional activation (CRISPRa).