ANGPTL3

Validation Data

Figure1. Analysis of ANGPTL3 gene expression on hepatocytes by RT-PCR in WT and ANGPTL3 humanized mice.

Mouse Angptl3 mRNA was detectable by P1/2(443bp), human ANGPTL3 mRNA was detectable by P3/4(345bp).

M:100bp Plus DNA ladder from Transgen (BM311). RT-PCR results showed that hepatocytes of the heterozygous KI mice express both human ANGPTL3 and mouse Angptl3.

Figure 2.  Analysis of human ANGPTL3 expression in serum by ELISA in the ANGPTL3 humanized mice. The heterozygous KI mice express human ANGPTL3 in serum.