TARGATT™ iPSC-iNK Platform
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iPSC Derived NK, CAR-T/CAR-NK Cell Generation
As natural killer (NK) cell-based cancer immunotherapy research continues to grow, so has the number of potential chimeric antigen receptor (CAR)-NK therapies. Researchers continue to explore the cytotoxic capabilities of engineered NK cells, but several CAR-NK cell generation problems remain. For example, the CAR-NK cell development process takes several weeks, the patient’s NK cells may be weak and in a damaged state, or cancer cells may be created with random integration. Recent advancements in induced pluripotent stem cell (iPSC) technology have opened the door for the development of CAR-iPSCs that can be further differentiated into NK cells. These cells could potentially fix the current CAR-NK problems the research community is facing.
Applied StemCell (ASC) combined its optimized TARGATT
TM
gene editing and NK differentiation technologies to establish the TARGATT
TM
iPSC-iNK Platform. Our expert scientists can insert your specific CAR genetic material into our iPSCs at a safe harbor locus with an efficiency ~10x better than CRISPR and further differentiate your CAR-iPSCs to high-quality NK cells. Leverage our unlimited source of iPSCs and proprietary TARGATT
TM
technology to safely and efficiently produce the allogenic iNK cells you need to drive your research forward.
ASC Advantages
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- >40% gene integration efficiency
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- Site-specific knock-in
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- NK cells derived from an unlimited source of iPSCs
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- iPSC-iNK cell banks with a consistent manufacturing process
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- Safe and efficient gene editing protocols
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- Transfection by lipofectamine, eliminating viral manufacturing
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- We generate truly off-the-shelf allogeneic therapeutic cells
As a CRO/CDMO service provider that continuously works to improve and expand its technology, services, and products, we hope to have our new cGMP TARGATT™ iPSCs available for purchase early next year. For now, we offer you fully characterized
cGMP grade iPSCs
from CD34+ cord blood.
Contact us
today to learn more.
Why Applied StemCell?
We understand working with iPSCs remains difficult, and you may encounter several challenges. At ASC our stem cell and gene editing experts are ready to help you every step of the way.
1. Send in your CAR design for review. Our experts can help you enhance your design.
2. Our team can design research and GMP projects in parallel OR generate a matching research grade cell line for preliminary testing.
3.
Downstream Assay Services Are Available
: cytotoxicity assays,
in vivo
testing, drug banking, and more –
Inquire
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