TMEM173

Humanized Gene Knock-in Strategy

Validation Data

Figure 1. The expression of human STING in CD4+ T lymphocytes of humanized STING mice was measured by FACS. In heterozygous humanized STING mice, active expression of human STING was detected in CD4+ T lymphocytes derived from blood, spleen, thymus and lymph node. 

Figure 2. The expression of human STING in CD8+ T lymphocytes of humanized STING mice was measured by FACS. In heterozygous humanized STING mice, active expression of human STING was detected in CD8+ T lymphocytes derived from blood, spleen, thymus and lymph node. 

Figure 3. The expression of human STING in the heart and lung cells was measured by FACS. In heterozygous humanized STING mice, active expression of human STING was detected in the heart and lung cells .