Quality Management & Regulatory

New Absolutely Zero-Off Target Base Editing Technology is now part of Applied StemCell’s Gene Editing Platform

If you are looking to edit multiple targets in a single cell with an efficiency similar to editing a single target without significant off-target events, AccuBase is your top choice on the market. Base editing is a newer genome editing approach that uses components from CRISPR systems together with other enzymes for point mutations in cellular DNA or RNA without making double-stranded DNA breaks (DSBs). Traditional base editors feature a deaminase attached to the Cas9 protein’s end. At ASC we use an AccuBase protein guided by sgRNA that can associate with your double-stranded DNA, undergo a structural change exposing the deaminase domain, and facilitate base editing.